Cell signaling is essential for cellular communication and adaptation to environmental changes. Our research focuses on the JAK/STAT signlaing pathway, a critical mediator of cytokine and growth factor responses that maintains tisssue homeostasis and drives the immune defence against infections. Dysregulation of the JAK/STAT pathway, however, can lead to tissue damage or autoimmmune diseases. By investigationf the organ- and cell-type specific roles of the JAK/STAT components TYK2 and STAT1, we aim to uncover fundamental mechanisms of immune defence against viral, bacterial and fungal infections.

Our lab employs state-of-the-art techniques, including multi-colour flow cytometry, advanced microscopy, and single-cell gene exression analysis, proteomics, alongside in vitro and in vivo models of antimicrobial immunity. Through this work, we aim to advance our understanding of immune signaling networks and contribute to the development of novel theraputic strategies for infectious and immune-mediated diseases.

We welcome collaborations and inquiries from researchers and students who share our passion for understanding the immune systen and its role in health and disease.

• Deciphering transcriptional and regulation by type II interferons (IFNs): Investigating how STAT1 and its isoforms shape the chromatin landscape, regulate gene expression and modulate secondary responses to other stimuli.

• Understanding infection-induced haematopoiesis: Exploring how infectins trigger blood cell production ooutside the bone marrow and hoow this is directed towards the cell types in demand.

• Elucidating the role of TYK2 in antifungal immunity: Uncovering how TYK2 contributes to the immune system's ability to combat fungal infections in the skin and systemically.

• Defining cell type-specific functins of STAT1 in antiviral defence: Investigating how STAT1 in lymphoid stromal cells and macropahges regulates immunity against viral infections.

© Sara Miranda: JAK/STAT signaling orchestrates transcriptional responses, immune and non-immune cell function and the immune defence against viral, bacterial and fungal infections.